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Discovery, chance and the scientific method

The discovery and development of penicillin

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concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2–4 weeks after a single IM dose. It is marketed by Wyeth under the trade name Bicillin L-A. Specific indications for benzathine pencillin include: (Rossi, 2004) Prophylaxis of rheumatic fever Early or latent syphilis edit Benzylpenicillin (penicillin G) Penicillin G (Benzylpenicillin) 3D-model of benzylpenicillin Benzylpenicillin, commonly known as penicillin G, is the gold standard penicillin. Penicillin G is typically given by a parenteral route of administration because it is unstable in the hydrochloric acid of the stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity. Specific indications for benzylpenicillin include: (Rossi, 2004) Cellulitis Bacterial endocarditis Meningitis Aspiration pneumonia, lung abscess Community-acquired pneumonia Syphilis Septicaemia in children edit Phenoxymethylpenicillin (penicillin V) Phenoxymethylpenicillin, commonly known as penicillin V, is the orally-active form of penicillin. It is less active than benzylpenicillin, however, and is only appropriate in conditions where high tissue concentrations are not required. Specific indications for phenoxymethylpenicillin include: (Rossi, 2004) Infections caused by Streptococcus pyogenes Tonsilitis Pharyngitis Skin infections Prophylaxis of rheumatic fever Moderate-to-severe gingivitis (with metronidazole) edit Pr